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The effectiveness of desensitization versus rechallenge treatment in HIV-positive patients with previous hypersensitivity to TMP-SMX: a randomized multicentric study

However, staying within the same anatomical region (e.g., alternating between abdomen sites rather than switching to thigh) may reduce absorption variability and improve dose predictability for patients with metabolic sensitivity to timing fluctuations

Satyanarayana K, Sravanthi K, Shaker IA, Ponnulakshmi R

And there remains an open regulatory question: the FDA has not yet established clear guidance on whether lean mass preservation alone can serve as a primary endpoint for drug approval